• Pompe disease is accompanied by the deficiency of the lysoso

  2024-12-10

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the cp-690550 unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in the st

• In our previous report we synthesized

  2024-12-10

  

  In our previous report, we synthesized derivatives with some straight chain residues on the 2-position of the 3-cyanopyridine ring of compound 1. In this time we tried to introduce aromatic ring on the chain of the 2-position. Namely, we replaced the hydroxyl-alkylamino group in the position 2 of t

• However most of these SBVS studies were

  2024-12-10

  

  However, most of these SBVS studies were focused on the target(s) for which crystal structures were available or have a similar template in PDB for comparative modeling. Besides, these were limited to SBVS only which relies on the rigid binding pocket, therefore, it may result in high false positive

• Rosiglitazone HCl br Materials and methods br

  2024-12-10

  

  Materials and methods Results Discussion Because the Ser/Thr kinase domain of LRRK2 is homologous to that of other MLK family proteins belonging to the MAP3K superfamily, LRRK2 is suggested to be involved in MAPK signaling and activation of neuronal cell death by phosphorylating its downstr

• Introduction Heterotrimeric G proteins mediate signal transd

  2024-12-10

  

  Introduction Heterotrimeric Gαβγ proteins mediate signal transduction through seven-transmembrane domain receptors. In response to neurotransmitters or hormones, activated receptors bind GTP via the Gα subunit leading to the dissociation of Gα from the Gβγ dimer. G proteins regulate the levels of s

• Moreover a multiple regression analysis using

  2024-12-09

  

  Moreover, a multiple regression analysis using the 1-year MMSE score as a dependent variable was conducted. The result showed that serum dextromethorphan hydrobromide levels at admission did not affect the MMSE score 1 year later (β = 0.10, p = 0.639). Discussion In this study, serum Aβ42 level

• multidrug resistant br Materials and methods br Results br D

  2024-12-09

  

  Materials and methods Results Discussion The transcriptional activity of PGC-1α is regulated by a number of stimuli, exemplifying the range of settings in which mitochondrial biogenesis is induced. The mechanisms governing this regulation have been extensively studied and have been determin

• br Material and methods br Results br Discussion

  2024-12-09

  

  Material and methods Results Discussion Aminopeptidase N is a transmembrane protease present in a wide variety of human tissues and cell types (endothelial, epithelial, fibroblast, leukocyte). APN expression is dysregulated in inflammatory diseases as well as in solid and hematologic tumors

• It has been reported that

  2024-12-09

  

  It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote Rivaroxaban injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, differential e

• br Role of autophagy in alcoholic cardiomyopathy br Concludi

  2024-12-09

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• br Conflict of interest br Acknowledgements

  2024-12-07

  

  Conflict of interest Acknowledgements Introduction The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling system that regulates diverse cellular functions, such as proliferation, differentiation, and apoptosis [1]. Apoptosis signal-regulating kinase 1 (A

• Recently competitive inhibitors of arginase have been

  2024-12-07

  

  Recently, competitive inhibitors of arginase have been developed which have greater specificity for the enzyme. Initial development of these compounds involved determination of the crystal structure of arginase. Christianson and colleagues found that a binuclear manganese cluster was required for ca

• br Funding This work was supported

  2024-12-07

  

  Funding This work was supported by the National Natural Science Foundation of China (grant No. 81573664). Thanks to Jing-xian Yang from the Pharmacology Laboratory of Liaoning University of Traditional Chinese Medicine for support with technology and experimental equipment. Disclosure Confl

• br Experimental section br Acknowledgements

  2024-12-07

  

  Experimental section Acknowledgements This work was funded by the Italian Association for Cancer Research (AIRC IG18590 to A.A.), by “Fondi di Ateneo-University of Pisa” years 2009 and 2010 (E. N., S. N., E. O., and A. R.) and partially by the Unipi project P.R.A.2016_27 (E. N., E.O. and A. R.

• br Current therapies for metabolic diseases Inborn errors of

  2024-12-07

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

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