• Main Text On behalf of

  2018-11-08

  

  Main Text On behalf of the International Society for Stem Cell Research (ISSCR) and the Stem Cell Reports’ editorial team, we would like to extend a warm welcome to you and present the inaugural issue of our journal, Stem Cell Reports. Stem Cell Reports is the ISSCR’s new journal, a highly visible

• As a component of the gene targeting

  2018-11-08

  

  As a component of the gene-targeting strategy used to delete Nanog, a neomycin-resistance gene was placed under control of its endogenous promoter (Chambers et al., 2007). Thus, selection with the neomycin analog G418 could be used to rule out the unlikely possibility that undifferentiated pluripote

• This is in accord with previous reports that astrocytes infl

  2018-11-08

  

  This is in accord with previous reports, that astrocytes influence both proliferation and differentiation of embryonic and adult neural stem cells, and specifically promote neurogenic fate of neural stem cells (Roy et al., 2006; Nakayama et al., 2003; Song et al., 2002). Factors that affect neural s

• The following are the supplementary data related to

  2018-11-08

  

  The following are the supplementary data related to this article. Acknowledgments The work in the author\'s laboratory is currently supported by the grants from NIH (GM093335), New York State (NYSTEM Contract# C026434) and American Heart Association (09SDG2400151). YS is partly supported by NIH

• Environmental oxygen levels affect tissue

  2018-11-08

  

  Environmental oxygen levels affect tissue vascularization and fracture healing. A previous study suggested that hyperoxia (50% O2 and 1ATA) increased tissue vascularization but did not significantly alter osteogenesis during the early stages of fracture healing (Lu et al., 2013). Most of the inspire

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Genotoxic stress and DNA damage are considered to be major causes of aging in mammals. The risk of mutation load and loss of genome integrity in adult stem cells has been proposed to be the principal cause of age related decline in tissue function (R

• Another important advantage of this technical

  2018-11-08

  

  Another important advantage of this technical report is the successful application of dCas9 activators for validation of PAX7 knock-in reporter DMH-1 (Cheng et al., 2013). By design and assembly of site-specific dCas9 activators for PAX7 in human iPS cells, these activators have been screened for in

• br Conclusion In summary we provided the

  2018-11-08

  

  Conclusion In summary, we provided the first evidence that FOXM1 plays an important role in the maintenance of cell proliferation in the hESC cell line VAL-3, with significant functions in safe-guarding progression through G2/M phase mediated by the transcriptional regulation of TAPI-1 genes inc

• Anti-diabetic Compound Library br Discussion We investigated

  2018-11-08

  

  Discussion We investigated whether CD133 serves as a putative epithelial stem/progenitor cell marker in adult murine prostates and explored its function in prostate regenerative capacity. We demonstrated that CD133 is not only expressed in a small fraction of prostate basal Anti-diabetic Compound

• Recent studies have proposed the involvement of

  2018-11-08

  

  Recent studies have proposed the involvement of CSCs/progenitor amphetamine sulfate in cancer initiation, progression, metastasis and therapy failure (Cariati and Purushotham, 2008; Gonzalez-Sarmiento and Perez-Losada, 2008; Lawson et al., 2009; Liu et al., 2005; Lynch et al., 2006; Ponti et al., 2

• We initially tested this system s capacity to

  2018-11-08

  

  We initially tested this system’s capacity to induce epigenetic reprogramming toward the SkM lineage in C3H10T1/2 bcrp transporter previously shown to readily undergo this transformation (Davis et al., 1987). We designed three separate gRNAs (1–3) targeted to different positions proximal to the Myod

• br Heteroplasmy mitochondrial segregation and disease In

  2018-11-08

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

• To understand how pluripotency is achieved we compared somat

  2018-11-08

  

  To understand how pluripotency is achieved, we compared somatic cell reprogramming with the acquisition of pluripotency in PGCs. Although these two phenomena are different, the obtained pluripotent stem pde-5 inhibitors have similar characteristics. Analysis of how pluripotent stem cells are genera

• In our initial attempts at simultaneous

  2018-11-08

  

  In our initial attempts at simultaneous reprogramming and gene targeting of somatic cells, we chose to target the DNMT3B gene with an EGFP reporter, since DNMT3B is highly expressed in pluripotent AZD1152 and quickly downregulated following differentiation, allowing targeted iPS cell colonies to be

• Exendin-4 Introduction Previous studies describing functiona

  2018-11-08

  

  Introduction Previous studies describing functional recovery following transplantation of neural stem/progenitor Exendin-4 (NS/PCs) in spinal cord injury (SCI) models demonstrated the therapeutic promise of this approach (Cummings et al., 2005; Iwanami et al., 2005). A number of putative underlyin

16419 records 1076/1095 page Previous Next First page 上5页 10761077107810791080 下5页 Last page