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To understand how pluripotency is achieved we compared somat
2018-11-08
To understand how pluripotency is achieved, we compared somatic cell reprogramming with the acquisition of pluripotency in PGCs. Although these two phenomena are different, the obtained pluripotent stem pde-5 inhibitors have similar characteristics. Analysis of how pluripotent stem cells are genera
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In our initial attempts at simultaneous
2018-11-08
In our initial attempts at simultaneous reprogramming and gene targeting of somatic cells, we chose to target the DNMT3B gene with an EGFP reporter, since DNMT3B is highly expressed in pluripotent AZD1152 and quickly downregulated following differentiation, allowing targeted iPS cell colonies to be
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Exendin-4 Introduction Previous studies describing functiona
2018-11-08
Introduction Previous studies describing functional recovery following transplantation of neural stem/progenitor Exendin-4 (NS/PCs) in spinal cord injury (SCI) models demonstrated the therapeutic promise of this approach (Cummings et al., 2005; Iwanami et al., 2005). A number of putative underlyin
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The role of Wnt catenin signaling in reprogramming has
2018-11-08
The role of Wnt/β-catenin signaling in reprogramming has also been investigated. Exogenously introduced WNT3A enhances fibroblast reprogramming in the absence of c-Myc (Marson et al., 2008). Knockdown or knockout of T cell factors or treatments with several drugs that control the Wnt pathway can cha
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Greater access to fast food chains translates into an
2018-11-07
Greater access to fast food chains translates into an environment with increased opportunities to purchase and consume such items (Brug, 2008; Thornton, Bentley & Kavanagh, 2009). As governments at the Federal, state, and local levels strive to find new ways to improve p-Cresyl sulfate health outco
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br Consideraciones finales Al respecto
2018-11-07
Consideraciones finales Al respecto hay que recordar que este problema de vulnerabilidad a los ciclos económicos externos orientó buena parte de los esfuerzos de la política económica aplicada en nuestro país durante varias décadas del siglo xx, sobre todo a partir de las décadas de los años trei
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The following are the supplementary data
2018-11-07
The following are the supplementary data related to this article. Contributors Declaration of interests Acknowledgements We thank Prof. Walter Keller from the University of Graz and Dr. Christoph Göbl from the Technical University of Munich for preparing the surface representation figures
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Besides beige adipogenesis increasing the progenitor pool
2018-11-07
Besides beige adipogenesis, increasing the progenitor pool in adipose tissues through angiogenesis has another advantage. It is known that PDGFRα+ progenitor Paprotrain are the source of both beige and white adipocytes (Lee et al., 2012; Lee et al., 2013; Lee et al., 2015). Thus, enhancing PDGFRα+
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A number of clinical proteomics studies have
2018-11-07
A number of clinical proteomics studies have generated a long list of candidate urine protein biomarkers of various diseases (Beretov et al., 2015; Goodison et al., 2009; Rodriguez-Suarez et al., 2014; Shao, 2015); however, no biomarkers derived from ‘discovery’ studies were successfully translated
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Mouse br Materials and Methods br
2018-11-07
Materials and Methods Results Discussion High-dose vitamin C has been studied in multiple cancers and has shown controversial clinical effects (Cameron and Pauling, 1978, 1976; Creagan et al., 1979; Moertel et al., 1985). The contradictory clinical results can be at least partially explaine
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The noninvasive EFVPTC lesions having follicular growth patt
2018-11-07
The noninvasive EFVPTC lesions having follicular growth pattern, particular microscopic architecture and nuclear features of PTC with low risk of malignancy have been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) (Nikiforov et al., 2016; Strickl
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br Tasas de inter s artificialmente bajas
2018-11-07
Tasas de interés “artificialmente bajas” Este fenómeno es lo que a sospecha de muchos (, Economist; 2016) ha provocado que el mundo viva con una inusual y extravagante liquidez global entre los mercados financieros de manera artificial. Como se aprecia en la gráfica 1, tanto las expectativas de
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Further information about the proposed D SEM surface reconst
2018-11-07
Further information about the proposed 3D SEM surface reconstruction framework along with several experimental validations are explained in [2]. Based on the history of downloads (Fig. 2), the 3DSEM appears to be a popular dataset in the research community. In the near future, we would very much li
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br Specification table br Value of the data br Data
2018-11-07
Specification table Value of the data Data Data on comparative antimycobacterial activity of total hydroethanolic extracts derived from five medicinal plant species is presented (Table 1). Data on in vitro cytotoxic activity of tested plant species and positive control drugs, isoniazid, rif
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br Acknowledgements The research work was support by the Sin
2018-11-07
Acknowledgements The research work was support by the Singapore Eye Research Institute Pilot Grant and Tan Tock Seng Hospital Pitch for Fund Grant. Data The dataset includes assay optimization and meta-data associated with measuring gene Dynasore cost kinetics of bacterial cold water disease
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