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Dgat mice however had less
2020-05-07
Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e
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In summary the loss of seven
2020-05-07
In summary, the loss of seven Cyp3a genes lead to sexual dimorphic changes during the eight weeks of high fat diet treatment with Cyp3a-null female mice showing a healthier acclimation to a high fat diet through decreased weight gain, higher adiponectin, lower B-OHB levels, and a better response to
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br Methods br Results Our study focused on
2020-05-07
Methods Results Our study focused on consecutive postural adjustments (CPAs) between IS and BS (the shaded areas on Fig. 2); that is to say, the Rx kinetics that occur after the end of an upper limb movement. It was dedicated to examining the main features of CPAs and the influence of movement
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WRTs AI AI and AI showed the same ST
2020-05-07
WRTs AI-82/1, AI-9-1 and AI-60 showed the same ST as was published by Dingle et al. in RTS 103, 013 and 097 (Dingle et al., 2011). WRTs 015 and 002 were assigned as WRTs 015-like and 002-like due to slight changes in their CE-ribotyping profiles; however, the ST of WRT 002-like (ST8) was identical t
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During ischemia the impact of CK
2020-05-07
During ischemia, the impact of CK2 on mitochondria varies in different organs/tissues. For example, CK2α upregulation during ischemia leads to disrupted mitochondrial homeostasis and mediates cardiomyocyte ischemic injury [31]. Specifically, ischemia/reperfusion (I/R) progressively increases CK2α to
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In contrast to AChE BuChE Table exhibited
2020-05-07
In contrast to AChE, BuChE (Table 2) exhibited a measurable time-dependent inactivation only with SC 79 2 among the four acetophenones in this study. Values of Ki obtained from steady-state inhibition of BuChE by all four acetophenones were, as noted in the Results, 10- to 200-fold greater (indicat
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VMD v Humphrey et al was used to
2020-05-06
VMD v1.9.2 (Humphrey et al., 1996) was used to analyze the MD trajectories, salt bridge interactions and secondary structure information from each frame. Once the model was optimized, the topological diagram and area and volume of protein cavities were analyzed using PDBsum (Laskowski, 2009) and CAS
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br Materials and methods Details on materials and methods ca
2020-05-06
Materials and methods Details on materials and methods can be found in the Supplemental material section. Results Discussion In our experiments we mimicked inflammation by LPS challenge of M0 macrophages. We discovered a strong increase in expression of CH25H and CYP7B1 while CYP27A1 and H
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Introduction Determining how genes function together as biol
2020-05-06
Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot
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Growing evidence has shown that ANS dysregulation indexed
2020-05-06
Growing evidence has shown that ANS dysregulation, indexed by heart rate variability (HRV), plays a critical role in the pathogenesis of anxiety (Minassian et al., 2014, 2015). Indeed, we have previously reported that patients with GAD are associated with reduced resting parasympathetical (vagal) co
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Due to its several industrial applications the recombinant p
2020-05-06
Due to its several industrial applications, the recombinant production of collagen and all its derivatives as gelatins has been pursued for many years in different biological systems as mammalian Fmoc-Ala-OH (Toman et al., 1999), tobacco plants (Ruggiero et al., 2000), silkworms (Tomita et al., 200
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Preparation of the pyridyl ether analogs was accomplished
2020-05-06
Preparation of the 2-pyridyl ether analogs (–) was accomplished by alkylation of alcohol with 2-bromopyridines in the presence of NaH to afford the desired pyridyl ether analogs in low to moderate yield. Preparation of the 3-pyridyl analog was carried out by conversion of alcohol to the tosylate,
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br O GlcNAcase Human OGA
2020-05-06
O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do
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HCV has evolved mechanisms to evade
2020-05-06
HCV has evolved mechanisms to evade humoral immune responses including high functional flexibility and variability of immunogenic portions of its envelope proteins. The highest sequence variability occurs in the first 27 GDC-0994 of the N-terminus of E2, which is referred to as the hypervariable re
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br Endothelial mechanotransduction br Apoptosis br Death ass
2020-05-05
Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the Flutamide synthesis network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endotheli
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