• br Introduction Mammalian proteases comprise both

  2020-03-16

  

  Introduction Mammalian proteases comprise both the peptidases or exopeptidases, which act at the N- or C-terminal positions of polypeptides, and proteinases or endopeptidases, which are capable of cleaving peptide bonds in the central regions of polypeptides. The endopeptidases are classified in

• At baseline mutant allele frequency of EGFR in tissue

  2020-03-13

  

  At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA

• The histologic finding that EBV infected B

  2020-03-13

  

  The histologic finding that EBV-infected CC-223 australia in infectious mononucleosis tend to avoid the GCs and instead accumulate under the epithelium of certain mucosal tissues34, 129 could be explained by the above-mentioned expression patterns of chemokine receptors on EBV-infected B cells. CXC

• AP26113 sale Since these first results KSTD activity has bee

  2020-03-13

  

  — Since these first results, Δ1-KSTD activity has been identified in many other microorganisms, albeit sometimes with different substrate preferences. For instance, Comamonas testosteroni ATCC 11996 (formerly Pseudomonas testosteroni) is active on several steroid substrates, but it cannot use 11β-hy

• Limitations of the current study in

  2020-03-13

  

  Limitations of the current study, in addition to the ones highlighted above, are its retrospective nature, the potential biased selection of patients requiring bronchoscopy for the etiological diagnosis of pneumonia, the lack of normalization of CMV DNA loads in BAL fluids to cellular DNA content (a

• In the present study the A P ratio in the

  2020-03-13

  

  In the present study, the A/P ratio in the MCF-7 cell line was significantly increased by the combination of 1 nM E2 and progestogens, except P4, as well as by10 nM E2 combined with NET. The similar findings were also noted by several reports [16], [17], [18], [19], [20] in which progestogens combin

• The acid base properties of

  2020-03-13

  

  3. The acid-base properties of the IL are important issues to consider because protonation changes caused by Brønsted-acidic or basic ions may result in enzyme deactivation [29]. Thereby, the acid-base properties of the newly designed IL need proper control for enzymes by selection of appropriate ca

• There are conflicting studies on ET axis

  2020-03-13

  

  There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c

• Nimodipine is an L type

  2020-03-13

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• TC-I 15 In pregnancy maternal uterine spiral artery SA

  2020-03-13

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK TC-I 15 (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and in mic

• br Acknowledgements The research leading

  2020-03-13

  

  Acknowledgements The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 − Scientia Fellows (JB) and the Research Council of Norway (NFR-grant 221444) (JB, JPM, OB). Introduction Hu

• Several main strategies for targeting E s described

  2020-03-13

  

  Several main strategies for targeting E3s described in the literature include: in vitro screening using functional assays [86]; computer programs for predicting potential druggable pockets, including those at protein-protein interfaces, and subsequent docking-based in silico ligand screening [87]; f

• br Acknowledgments br Introduction Ubiquitin

  2020-03-13

  

  Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr

• In summary the reduction of one or more pro

  2020-03-12

  

  In summary, the reduction of one or more pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, IL-8 was observed in almost all the monoterpenes studied. Increased levels of the anti-inflammatory cytokine IL-10 was shown to play a prominent function in the anti-inflammatory effect of monoterpenes,

• Introduction The carnitine choline acyltransferase family is

  2020-03-12

  

  Introduction The carnitine/choline acyltransferase family is a family of enzymes that play diverse roles, ranging from (the regulation of) mianserin and fuel metabolism in mitochondria and peroxisomes to the generation of the neurotransmitter acetylcholine. In mammals, this family consists of seve

15606 records 842/1041 page Previous Next First page 上5页 841842843844845 下5页 Last page