• Recent studies showed that the activity of CK was

  2020-08-03

  

  Recent studies showed that the activity of CK2 was significantly reduced in ischemic stroke model rats, and cerebral I/R injury significantly decreased the expression of CK2α (Lee et al., 2004; Kim et al., 2012; Zhou et al., 2016). In addition, the dysregulation of CK2 is involved in ERS/UPR in non-

• In summary our study provides a novel insight

  2020-08-03

  

  In summary, our study provides a novel insight into the regulation of MGMT in cancer cells. We demonstrated for the first time that UBE2B and its partner RAD18 are involved in regulating the ubiquitination and activity of MGMT. The regulation of MGMT by UBE2B can affect the sensitivity of cancer cel

• Phosvitin PV is a highly phosphorylated protein from

  2020-08-03

  

  Phosvitin (PV) is a highly phosphorylated protein from egg yolk (Byrne et al., 1984). Phosvitin and its derived phosvitin hydrolysate (PVH) were reported to exert various physiological activities such as anti-inflammatory activity (Hu et al., 2013, Xu et al., 2012, Young et al., 2011), antioxidant a

• There are two genes encoding DEAH

  2020-08-03

  

  There are two genes encoding DEAH/RHA helicases in Escherichia coli (Ec), HrpA (Hypersensitive Response and Pathogenicity A) and HrpB (Hypersensitive Response and Pathogenicity B) [16]. HrpA has been shown to be important in mRNA processing, ATP binding, hydrolysis ability and dsRNA unwinding in vit

• Therefore P falciparum DHODH PfDHODH represents a target

  2020-08-03

  

  Therefore, P. falciparum DHODH (PfDHODH) represents a target for the discovery and development of parasite-specific inhibitors that could lead to promising antimalarial lead compounds [18,23]. Different chemical scaffolds have been identified as potent inhibitors of PfDHODH that show strong selectiv

• DDR is characterized by an

  2020-08-03

  

  DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of cantharidin level in cancer tissues and biological functions in normal and cancer cell conditions, but ch

• br Introduction The cytochrome p family subfamily

  2020-08-01

  

  Introduction The cytochrome p450 family 2, subfamily D, polypeptide 6 (CYP2D6) enzyme is responsible for phase I metabolism of approximately 30% of marketed drugs and endogenous toxins [1], [2]. CYP2D6 is a highly variable pharmacogene with well documented allele distributions that vary by demogr

• Therefore based on the previous studies we hypothesized that

  2020-07-31

  

  Therefore, based on the previous studies, we hypothesized that curcumin supplementation can reduce intestinal cholesterol CNQX in ApoE knockout (ApoE−/−) mice and prevent atherosclerosis development. To test our hypothesis, we used high-fat diet–fed ApoE−/− mice, genetically modified mice commonly

• Several CHK inhibitors have been reported

  2020-07-31

  

  Several CHK-1 inhibitors have been reported in the literature. Of these, UCN-01 (7-hydroxystaurosporine) is a potent inhibitor of CHK-1 (=5.6nM), , and has modest selectivity among other kinases. UCN-01 is currently in clinical trials. Other CHK-1 inhibitors reported in the literature include indaz

• The following are the supplementary data

  2020-07-31

  

  The following are the supplementary data related to this article. Transparency document CDKs and their Regulation CDKs are multifunctional enzymes that can modify various protein substrates involved in the cell cycle. Human cells have 13 CDKs that interact with at least 29 cyclins or cyclin-r

• The identification of substrate binding

  2020-07-31

  

  The identification of substrate binding surface and mediated ubiquitination activity provides significant evidence supporting the development of small molecule E3 inhibitors (Fig. 1) [6]. But in view of the overall protein subunit arrangements combined with the need for small molecule inhibitors to

• The structure of the HOIP RBR LDD module bound

  2020-07-31

  

  The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi

• Prior research has identified the upregulation

  2020-07-31

  

  Prior research has identified the upregulation of ABCF1, in TNF-α-stimulated synoviocytes from rheumatoid arthritis patients (Richard et al., 1998). While retaining its ATP-binding cassette, ABCF1 is unusual as it lacks a transmembrane domain and does not function as a transporter. ABCF1 is thought

• While apparent that His Artemis fractionated over a

  2020-07-31

  

  While apparent that [His]6-Artemis fractionated over a HAP column is devoid of 5′–3′ exonuclease activity but still retains DNA-PK dependent hairpin-opening activity, we sought to further assess DNA-PK dependent Artemis overhang cleavage activity to ensure all the in vivo, intrinsic enzymatic activi

• br Development of the double strand break repair model for

  2020-07-31

  

  Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using MRE 3008F20 receptor in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thom

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