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DDR is characterized by an
2020-08-03
DDR2 is characterized by an N-terminal discoidin domain and a C-terminal kinase domain [7]. Characteristics of DDR1, which is a homologue of DDR2, have been extensively investigated in terms of cantharidin level in cancer tissues and biological functions in normal and cancer cell conditions, but ch
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br Introduction The cytochrome p family subfamily
2020-08-01
Introduction The cytochrome p450 family 2, subfamily D, polypeptide 6 (CYP2D6) enzyme is responsible for phase I metabolism of approximately 30% of marketed drugs and endogenous toxins [1], [2]. CYP2D6 is a highly variable pharmacogene with well documented allele distributions that vary by demogr
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Therefore based on the previous studies we hypothesized that
2020-07-31
Therefore, based on the previous studies, we hypothesized that curcumin supplementation can reduce intestinal cholesterol CNQX in ApoE knockout (ApoE−/−) mice and prevent atherosclerosis development. To test our hypothesis, we used high-fat diet–fed ApoE−/− mice, genetically modified mice commonly
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Several CHK inhibitors have been reported
2020-07-31
Several CHK-1 inhibitors have been reported in the literature. Of these, UCN-01 (7-hydroxystaurosporine) is a potent inhibitor of CHK-1 (=5.6nM), , and has modest selectivity among other kinases. UCN-01 is currently in clinical trials. Other CHK-1 inhibitors reported in the literature include indaz
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The following are the supplementary data
2020-07-31
The following are the supplementary data related to this article. Transparency document CDKs and their Regulation CDKs are multifunctional enzymes that can modify various protein substrates involved in the cell cycle. Human cells have 13 CDKs that interact with at least 29 cyclins or cyclin-r
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The identification of substrate binding
2020-07-31
The identification of substrate binding surface and mediated ubiquitination activity provides significant evidence supporting the development of small molecule E3 inhibitors (Fig. 1) [6]. But in view of the overall protein subunit arrangements combined with the need for small molecule inhibitors to
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The structure of the HOIP RBR LDD module bound
2020-07-31
The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi
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Prior research has identified the upregulation
2020-07-31
Prior research has identified the upregulation of ABCF1, in TNF-α-stimulated synoviocytes from rheumatoid arthritis patients (Richard et al., 1998). While retaining its ATP-binding cassette, ABCF1 is unusual as it lacks a transmembrane domain and does not function as a transporter. ABCF1 is thought
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While apparent that His Artemis fractionated over a
2020-07-31
While apparent that [His]6-Artemis fractionated over a HAP column is devoid of 5′–3′ exonuclease activity but still retains DNA-PK dependent hairpin-opening activity, we sought to further assess DNA-PK dependent Artemis overhang cleavage activity to ensure all the in vivo, intrinsic enzymatic activi
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br Development of the double strand break repair model for
2020-07-31
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using MRE 3008F20 receptor in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by Thom
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The irreversible binding of the alkyl group
2020-07-30
The irreversible binding of the alkyl group to MGMT protein functionally inhibits its enzyme activity and leads to protein degradation [8]. Proteasomal and lysosomal degradation are the two major processes for cellular protein turnover [9]. Protein ubiquitination is a chemical process in which ubiqu
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The in vivo anti inflammatory effect of
2020-07-30
The in vivo anti-inflammatory effect of Nemonapride australia was further completed using the functional model of adjuvant induced arthritis (AIA) in rats as shown in . Compound was shown to be active in the AIA model, although with a lower potency than teriflunomide. These results are not surpr
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Another class of transcription factors the members of
2020-07-30
Another class of transcription factors, the members of which are also expressed during the growth of cereal seeds, is the DOF (DNA-binding One Zinc Finger) family. The members of this class are characterized by a zinc-finger domain that binds to the prolamin box located in the promoters of genes enc
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In conclusion an electrophilic fragment library was
2020-07-30
In conclusion, an electrophilic fragment library was evaluated for inhibitory activity against the cathepsin-L like cysteine protease rhodesain. The unique feature of this approach is that reactive compounds were screened in an enzymatic assay in a 384 well plate format to identify specific hits, wh
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Keeping in mind the proposed
2020-07-30
Keeping in mind the proposed role of CICs in tumor growth and drug resistance [[23], [24], [25]], we focused mainly on factors related to CICs. Mo-treated colonospheres and tumors contained significantly less ALDH1 protein. ALDH1 is regarded as a CSC marker that belongs to a family of cytosolic (and
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