• Tibolone is also efficacious on bone

  2021-08-27

  

  Tibolone is also efficacious on bone in elderly women and induces a clear reduction in bone turnover markers [50], [51]. Rymer et al. showed that, after 10 years of treatment with tibolone, the difference in bone mineral density compared with a placebo group was more than 12% for both lumbar spine a

• Several large scale clinical studies

  2021-08-27

  

  Several large-scale clinical studies have set out with the common goal to further understand the cognitive impact of menopause and hormone therapies taken by women (Gleason et al., 2015, Greendale et al., 2011, Karlamangla et al., 2017, Rapp et al., 2003, Shumaker et al., 2003). Only one human study

• The pathogenesis of formation of an intradural

  2021-08-27

  

  The pathogenesis of formation of an intradural tumor is unclear. Initially, several lines of evidence suggested a neural crest cell of origin for Ewings’s sarcoma based on expression of neuroectodermal markers on tumor mocetinostat [45,46]. However more recently, studies have shown that expression o

• Another interesting finding regarding substrate selectivity

  2021-08-27

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty XEN445 receptor at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may consti

• br Methods br Results br

  2021-08-26

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific harmine hydrochloride australia organs (Donadio et al., 2005, Donadio et al., 20

• br Results and discussion In

  2021-08-26

  

  Results and discussion In the present study, we used a set of compounds (Fig. 2) consisting of ATP (a), dATP (b), an ATP analog containing β,γ-nonhydrolyzable hypophosphate P-P bond (c), and three pairs of P-diastereoisomers of α-thio-ATP analogs (d,e,f) containing a sulfur Fluoxymesterone instea

• ASC was reported as a potent antiviral and antifungal agent

  2021-08-26

  

  ASC was reported as a potent antiviral and antifungal agent, and its derivatives could modulate a variety of physiological activities, such as anti-tumor, anti-metastatic, and anti-diabetic activities in animals. Mie Tsuruga et al. found that 4-o-methylascochlorin had immunosuppressive activity, but

• br Experimental All starting materials and reagents were

  2021-08-26

  

  Experimental All starting materials and reagents were purchased from Sigma-Aldrich, Merck and Loba Chemie. Thin layer chromatography (TLC) was performed on silica gel G60 F254 (Merck) plates and eluted with the mobile phase n-hexane: ethyl acetate (70:30%v/v). Melting points were recorded on auto

• The lungs dissected from week mice were

  2021-08-26

  

  The lungs dissected from 4–5-week mice were cut into small pieces and then immersed in Dulbecco's modified Eagle's medium (Invitrogen, Carlsbad, CA) containing collagenase II (2 mg/ml), trypsin (2.5 mg/ml), Dnase I (2 mg/ml), penicillin (100 U/ml), and streptomycin (100 μg/ml) for 12 hours at 37 °C

• Our finding that activating DDR variants are a cause of

  2021-08-26

  

  Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho

• azidothymidine br Transparency document br Acknowledgements

  2021-08-26

  

  Transparency document Acknowledgements This work was supported by research grant G092715N of the Research Foundation Flanders (FWO). The authors are indebted to Drs. V. Baekelandt and E. Lobbestael (Research Group for Neurobiology and Gene Therapy, KU Leuven) for stimulating discussions and he

• Although DAPK has been implicated

  2021-08-26

  

  Although DAPK has been implicated in neuronal death in ischemic stroke and neurodegenerative diseases, such as Alzheimer’s disease (Shamloo et al., 2005, Duan et al., 2013), the mechanisms about how DAPK regulates cell death are still elusive. In the present study, we investigated the signal transdu

• ML-090 Based on the finding described above the present

  2021-08-26

  

  Based on the finding described above, the present study was designed to investigate the effects of specific CRF receptors, CRF1 and CRF2, in the BLA and CeA on the duration of TI in guinea pigs (Cavia porcellus). To this end, we evaluated whether administration of the CRF1 ML-090 antagonist CP-3763

• Park et al expanded their own model as hydrogen

  2021-08-26

  

  Park et al. [34] expanded their own model as hydrogen- bonding lattice fluid EOS (NLF-HB) [35] for calculating the activity coefficients of aqueous amino NVP-BGJ398 phosphate solution. Further, Pazuki et al. [36] extended the perturbed hard chain theory which has been proposed by Beret and Prausnit

• br Acknowledgment br Introduction Pesticides are largely use

  2021-08-26

  

  Acknowledgment Introduction Pesticides are largely used in agriculture to enhance food production and, to a lesser extent, to control unwanted pests and disease vectors in public health. However, these compounds are often associated with toxicity in non-target species including humans. Occupat

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