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Molecular dynamics studies have proved an effective means of
2021-09-23
Molecular dynamics studies have proved an effective means of characterising transition state pathways between the inward- and outward-facing states, and providing the relative propensity for each state. For example, long-timescale simulations of the membrane-embedded LeuT dimer, totalling ∼21 μs, ha
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br Conflict of interest br Funding br
2021-09-23
Conflict of interest Funding Acknowledgements Introduction to SLC6 transporters The solute carrier (SLC) 6 family of membrane proteins perform the Na+-coupled symport of amino acids and amino protease inhibitors hiv derivatives into cells throughout the body. Disrupting neurotransmitter
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Lamivudine synthesis Multiple mechanisms have been suggested
2021-09-23
Multiple mechanisms have been suggested by which glucagon can increase energy expenditure although none have been conclusively proven to be responsible. Both enhanced gluconeogenesis and enhanced protein turnover secondary to hyperglucagonaemia have been suggested as the reason for the increased met
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A few previous studies have examined Factor Xa
2021-09-22
A few previous studies have examined Factor Xa inhibitors for VTE prophylaxis in hip fracture patients. In a 2001 paper, Eriksson et al. studied 1250 patients with hip fractures that had been randomized to either postoperative Factor Xa inhibitor or enoxaparin [13]. Each patient received bilateral v
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salubrinal br Materials and methods br Results
2021-09-22
Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa salubrinal to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the total cell
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Methods br Results br Discussion SV exocytosis
2021-09-22
Methods Results Discussion SV exocytosis from excitatory boutons is more sensitive to inhibition by isoflurane than exocytosis from inhibitory boutons,4, 31 but the mechanism(s) of this synaptic selectivity is unknown. Although P/Q-type VGCCs contributed quantitatively more to SV exocytosis t
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Glycine released from astrocytes as well as neurons is also
2021-09-22
Glycine released from astrocytes as well as neurons is also known as a co-agonist of NMDAR (Roux and Supplisson, 2000). Neuronal glycine in mouse hippocampus might be released from glutamatergic terminals (Muller et al., 2013) that express functional find more information receptors (Rodriguez et al
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The multiple regression analysis showed that testing during
2021-09-22
The multiple regression analysis showed that testing during summer and autumn was associated with higher histamine reactivity, which could be associated with the presence of pollen in the air. Gamboa et al. reported that more histamine was released during spring and autumn than during the other two
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One limitation of our study was
2021-09-22
One limitation of our study was that all control dogs had histologic evidence of mild GI inflammation according to established WSAVA guidelines (Washabau et al., 2010), despite being apparently healthy purpose-bred research dogs housed in a controlled environment with no history of vomiting, diarrhe
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MRS 2578 br Dynamic Localization of Hippo Pathway Component
2021-09-22
Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i
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Different SVR rates have been observed when comparing GT
2021-09-22
Different SVR rates have been observed when comparing GT 1a- and 1b-infected patients receiving BOC or TLP therapy. The response rates in patients infected with GT 1b have generally been more favourable than in those with GT 1a [26]. In our study, persistence mutations were only observed in HCV GT 1
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Z-WEHD-FMK The second approach to optimizing microsomal stab
2021-09-22
The second approach to optimizing microsomal stability in this series involved the strategic positioning of steric bulk along the tether as a means of encumbering the access of oxidative enzymes to the methylene bridge. This approach has been employed in other P2-P4 macrocyclic inhibitors of NS3/4A
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Fibronectin protein level was not affected by DIF although
2021-09-22
Fibronectin protein level was not affected by DIF-1, although fibronectin has also been considered a canonical Wnt signaling pathway target gene product [39]. Thus, the canonical Wnt signaling pathway may not be critical for the regulation of the expression of fibronectin in malignant melanoma cells
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The ketone body receptor HCA is most likely
2021-09-22
The ketone body receptor HCA2 is most likely not active under normal conditions, since local levels and plasma levels of ketone bodies such as β-HB are too low to activate the receptor. However, overnight fasting or prolonged starvation results in plasma levels of the ketone body in the millimolar r
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In both families GPR A mRNA in
2021-09-22
In both families, GPR109A mRNA in kidney fat was positively correlated with NEFA as a tendency. A positive correlation between this fat depot and insulin was observed in lean-type cows. In fat-type cows, mesenteric GPR109A mRNA correlated positively with insulin and negatively with urea on a moderat
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