• br Molecular aberrations in the

  2022-05-27

  

  Molecular aberrations in the FGFR signaling pathway Non–small cell lung cancer Small cell lung cancer Integrated Madecassic acid mg analysis revealed focal amplification of FGFR1 in 6% of SCLC cases. In another study with PD173074, Pardo et al. used two human SCLC xenograft models, H-510 a

• Compounds were tested for GPR

  2022-05-27

  

  Compounds , were tested for GPR40 activity in a functional assay monitoring calcium flux in CHO Clindamycin HCl transiently transfected with human GPR40 gene. As shown in , compound was found to be a nanomolar GPR40 agonist, while compound was much less potent than . To explore the structure activit

• br Introduction The nature of chemotherapies is

  2022-05-27

  

  Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer custom synthesis via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by pro

• Caspase-8, human recombinant protein br Results br Discussio

  2022-05-27

  

  Results Discussion CD8 T Caspase-8, human recombinant protein are important for immune control of many viral infections (Ehtisham et al., 1993, Kagi et al., 1994, Mullbacher et al., 1999, Walsh et al., 1994). CD8 T cells are essential for efficient clearance of MAV-1 from the lungs and for air

• According to the World Health Organization WHO

  2022-05-27

  

  According to the World Health Organization (WHO) classification, oligodendrogliomas or anaplastic oligodendrogliomas are primary neoplasms of the central nervous system, which are predominantly composed of cells morphologically resembling oligodendrocytes [23]. These tumors are often estimated to re

• br Experimental br Acknowledgments br Human

  2022-05-27

  

  Experimental Acknowledgments Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS), and without treatment results in a debilitating disease that cripples the immune system of the patient, increasing susceptibility to opportunistic diseases

• Two US FDA approved assays are commonly used

  2022-05-27

  

  Two US FDA-approved assays are commonly used for VL monitoring: the COBAS AmpliPrep/COBAS® Taqman® HIV-1 version 2.0 (“CAP/CTM HIV-1 v2”; Roche Molecular Systems) [18], and the RealTime HIV-1 assay (“RealTime HIV-1”, Abbott Molecular) [19]. Several studies have shown good correlation between the ass

• In mammalian cells Motins have been identified as a

  2022-05-27

  

  In mammalian cells, Motins have been identified as a key link between F-actin and Hippo pathway regulation, as knockdown of all three Motins increased Yap activity even in the presence of cytoskeletal disruption [105]. Motins can physically associate with F-actin but this association is blocked by p

• According to the experimental data HKI preferentially binds

  2022-05-27

  

  According to the experimental data, HKI preferentially binds to the mitochondrial inter-membrane contact sites formed by ANT and VDAC [[5], [6], [7],27], mainly via the VDAC1 isoform [7,8]. These electrogenic contact sites allow application of a part of IMP to MOM by transferring phosphoryl groups f

• Lieber have discussed alcohol outside the context of hepatit

  2022-05-27

  

  Lieber (2000), have discussed alcohol outside the context of hepatitis C infection exerts specific pathologic effects on the liver. Liver biopsies in patients with hepatitis C who drink alcohol are generally consistent with hepatitis C alone, with portal-based pathology, rather than alcoholic injury

• br All platelet agonists acting through specific

  2022-05-27

  

  All platelet agonists, acting through specific receptors and triggering different signaling pathways, activate phospholipases (PLCß or PLCγ) and the subsequent messengers inositol 1,4,5-trisphosphate (IP3) and 1,2 diacylglycerol which activate inositol 1,4,5-trisphosphate (IP3) receptors (IP3R) or

• Our results show furthermore that higher concentrations of b

  2022-05-27

  

  Our results show furthermore, that higher concentrations of butyric RN486 additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of GSTP1 expression rem

• br Other Functions of HCA Receptors HCA

  2022-05-27

  

  Other Functions of HCA Receptors HCA receptors, in particular HCA1, are expressed in various primary tumor ONC201 77, 78, 79. This is of interest, as most solid tumors show increased glucose uptake and lactate formation even under normoxic conditions, with lactate concentrations in the tumor micr

• br Introduction High dose niacin

  2022-05-26

  

  Introduction High dose niacin, or nicotinic acid, has been used as an athero-protective drug for more than 50 years (Carlson, 2005, Offermanns, 2006). When taken in pharmacological doses (>1g/day), the nicotinic Valrocemide form of niacin modulates plasma lipid profiles including decreasing circu

• br Introduction Anthocyanidins and anthocyanins glycosides

  2022-05-26

  

  Introduction Anthocyanidins and anthocyanins (glycosides of anthocyanidins) are flavonoid phenolic compounds that are among the most common types of plant pigments [1]. They typically are responsible for the red, orange, blue, and violet colors in flowers, fruits, and vegetative tissues [1], [2].

15673 records 411/1045 page Previous Next First page 上5页 411412413414415 下5页 Last page