• Recently denosumab demonstrated a significant delay in the

  2019-05-08

  

  Recently, denosumab demonstrated a significant delay in the onset of detectable bone lesions in men with castration resistant prostate cancer compared to placebo . This could indicate some kind of efficacy of the compound as anticancer agent and consequently an indirect confirmation of the role of R

• br In their policy analysis Yusra

  2019-05-08

  

  In their policy analysis, Yusra Ribhi Shawar and colleagues (August, 2015) outline the complex responses needed to make surgery a global health priority, highlighting as a major challenge that “consensus needs to be reached on solutions”. Professional interests might have forestalled consensus on

• En conclusi n vivir bien buen vivir no son

  2019-05-08

  

  En conclusión, vivir bien/buen vivir no son por el momento nuevos paradigmas, pese a que, por ejemplo, los autores del Plan Nacional para el Buen Vivir de Ecuador (2009-2013) se referan a una transición del concepto de desarrollo al buen vivir en los términos de un “cambio de para-digma”. En estos t

• br In the past year migration

  2019-05-08

  

  In the past year, migration to Europe from Africa and the Middle East has reached unprecedented levels. In 2016, 181 405 migrants reached the shores of Italy and more than 5000 died trying to reach the southern coasts of Europe. Many migrants seek to escape war, poverty, persecution, or ill treatm

• The STAR VT trial is a randomized trial examining the

  2019-05-08

  

  The STAR-VT trial is a randomized trial examining the role of ablation in patient with an indication for ICD implantation [97]. The inclusion criteria targeting 562 patients with secondary prevention indications as well as primary prevention patients with inducible VT, where nonischemic cardiomyopat

• ion channels Generally patients with VVS do not need continu

  2019-05-08

  

  Generally, patients with VVS do not need continuous cardiac pacing, but require physiological pacing only at the moment of the vasovagal response. Petersen et al. [7] reported the efficacy of permanent DDI pacing with rate hysteresis in selected patients who presented with cardioinhibitory VVS. Prev

• Introduction Researchers have long followed

  2019-05-08

  

  Introduction Researchers have long followed the strategy that in order to achieve a fuller understanding of the causes of disease and how they can be prevented, it is necessary to study the biochemical and physiological processes involved in the etiology of disease. As I have argued in previous pap

• Nevertheless we believe that the main findings of our study

  2019-05-07

  

  Nevertheless, we believe that the main findings of our study are robust. We noted a progressive increase in the prevalence of rheumatic angiotensin receptor blocker disease with advancing age of children, modelling different prevalence patterns across age groups separately for each study, and pooli

• In contrast median Cu level mg L in our study

  2019-05-07

  

  In contrast, median Cu level (0.73 mg/L) in our study was approximately 50% lower than that in maternal blood (1.47 mg/L). Our result is consistent with several previously published studies, which showed a 50–60% decrease in Cu level in the fetus. The observed decrease in fetal Cu, a major metallic

• Besides MPO the infiltrated neutrophils in IR injured liver

  2019-05-07

  

  Besides MPO, the infiltrated neutrophils in IR injured liver can produce INFγ to enhance TLR4 signaling, stimulate KCs activation, and induce Th1 inflammation responses. Subsequently, M1/Th1 recommended reading produce INFγ to enhance neutrophil infiltration in the process of hepatic and renal IR in

• Introduction Atrial fibrillation AF is the

  2019-05-07

  

  Introduction Atrial fibrillation (AF) is the most common arrhythmia in adults and the most common cause of embolic stroke. AF affects approximately 0.8 million patients in Japan alone, and its incidence is expected to grow exponentially [1–3]. However, the electrophysiological mechanisms of the ini

• Introduction Verapamil sensitive idiopathic left

  2019-05-07

  

  Introduction Verapamil-sensitive idiopathic left ventricular tachycardia (ILVT) has been shown to be a clinical entity of left-sided idiopathic ventricular tachycardia (VT) [1,2]. In electrophysiological studies, two specific local potentials, the diastolic Purkinje (Pd) potential and presystolic P

• LYL belongs to the basic helix loop helix

  2019-05-07

  

  LYL1 belongs to the basic helix-loop-helix (bHLH) transcription factor family, which plays important roles in a variety of developmental processes, including hematopoiesis [6]. The biological function of LYL1 is largely unknown, but its expression is restricted to hematopoietic cells, including myel

• Demand for kidney transplantation for ESKD has

  2019-05-07

  

  Demand for kidney transplantation for ESKD has already outstripped the supply of donated pdgfr from living donors, notwithstanding the inadequate donor pool. End-of-life donation can potentially expand the donor pool but is less common. For example, in India, among the 12 294 renal transplantations

• In conclusion we observed that the

  2019-05-07

  

  In conclusion, we observed that the rate of carbapenem-resistant A. baumannii was high among burn patients. In addition, the most effective drugs against A. baumannii in vitro were colistin and polymyxin B. Since resistant isolates only had blaOXA-23-like and blaOXA-24-like, it seems that carbapene

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